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Nuvenzepine NEW

Price	$1520	$1980	$2500
Package	25mg	50mg	100mg

Min. Order:
Supply Ability:	10g
Update Time:	2025-07-17

Product Details

Product Name: Nuvenzepine	CAS No.: 96487-37-5
Supply Ability: 10g	Release date: 2025/07/17

Product Introduction

Bioactivity

Name	Nuvenzepine
Description	Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.
In vitro	Nuvenzepine demonstrates nearly equal potency to pirenzepine in competitively inhibiting bethanechol-induced gallbladder contractions and exhibits a four-fold greater potency in preventing vagal-stimulated tracheal constrictions. Additionally, it has a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions in both isolated ileal musculature and longitudinal ileum dispersed cells [1].
In vivo	Nuvenzepine, distinct from pirenzepine, actively moderates colonic motility and, when administered intraduodenally in anaesthetized cats, exhibits a prolonged, dose-dependent suppression of neostigmine-induced intestinal movement. This compound significantly reduces gastric acid secretion and intestinal hypermotility in rats while manifesting minimal atropine-like side effects. It is characterized by slow oral absorption, with an absolute bioavailability of 30 to 40%, slow elimination, negligible accumulation in the body, and minimal metabolism. Notably, Nuvenzepine's efficacy in inhibiting ileal motor activity is tenfold that of pirenzepine and demonstrates a 25-30 times higher potency in suppressing pentagastrin-stimulated gastric acid secretion in conscious cats, indicating its significant therapeutic potential.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Keywords	Nuvenzepine \| mAChR
Inhibitors Related	Osimertinib \| Lidocaine Hydrochloride hydrate \| Lapatinib \| Afatinib Dimaleate \| Erlotinib hydrochloride \| Erlotinib \| Neratinib \| Chalcone \| Osimertinib mesylate \| Genistein \| Khellin \| Gefitinib

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.