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Postion:Product Catalog >Nrf2-ARE/hMAO-B/QR2 modulator 1
Nrf2-ARE/hMAO-B/QR2 modulator 1
  • Nrf2-ARE/hMAO-B/QR2 modulator 1

Nrf2-ARE/hMAO-B/QR2 modulator 1 NEW

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Package 1removed
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Supply Ability: 10g
Update Time: 2025-05-21

Product Details

Product Name: Nrf2-ARE/hMAO-B/QR2 modulator 1 Supply Ability: 10g
Release date: 2025/05/21

Product Introduction

Bioactivity

NameNrf2-ARE/hMAO-B/QR2 modulator 1
DescriptionNrf2-ARE/hMAO-B/QR2 modulator 1, a new resveratrol-based multitarget-directed ligand (MTDL), exhibits a well-balanced MTDL profile: it activates the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibits both hMAO-B and QR2 (IC50s = 8.05 and 0.57 μM), and effectively promotes hippocampal neurogenesis. It exerts neuroprotective and antioxidant actions in both acute and chronic Alzheimer models using hippocampal tissues.
In vitroNrf2-ARE/hMAO-B/QR2 modulator 1 (compound 4e) (100 μM; 24 hours) reduces SH-SY5Y cell viability by approximately 30% in the MTT assay[1]. When pre-treated at 1 μM for 24 hours and then coincubated for another 24 hours with 10 nM okadaic acid (OA), it significantly increases cell viability of OA-treated rat primary cortical neurons to 70-80%, counteracting the 50% viability reduction caused by OA alone[1]. At 10 μM, it exhibits the highest expression of young cells (TuJ-1) and mature neurons (MAP-2), and the greatest cell migration distance, indicating strong neurogenic potential[1]. Additionally, at 1 μM for 72 hours, it provides neuroprotection, reduces cell death, and significantly decreases ROS production in mouse hippocampal slices exposed to OA[1].
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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