Nootkatone

Modify Date: 2024-01-02 22:30:18

Nootkatone structure	Common Name	Nootkatone
	CAS Number	4674-50-4	Molecular Weight	218.335
	Density	1.0±0.1 g/cm3	Boiling Point	318.6±42.0 °C at 760 mmHg
	Molecular Formula	C15H22O	Melting Point	35-39oC
	MSDS	ChineseUSA	Flash Point	142.1±18.7 °C
	Symbol	GHS07	Signal Word	Warning

Purity		Quantity		Budget		Inquiry

Use of Nootkatone Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].

• Properties

• Articles26

• Spectrum

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 Names

Name	(+)-Nootkatone
Synonym	More Synonyms

 Nootkatone Biological Activity

Description	Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Nootkatone (10?mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10?mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10?mg/kg) decreased the high expression of these inflammatory cytokines[1].
References	[1]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85. [2]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85.

 Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	318.6±42.0 °C at 760 mmHg
Melting Point	35-39oC
Molecular Formula	C15H22O
Molecular Weight	218.335
Flash Point	142.1±18.7 °C
Exact Mass	218.167068
PSA	17.07000
LogP	3.84
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.503
Storage condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	Slightly soluble in ethanol and chloroform. Partly soluble in water.

 MSDS

Nootkatone MSDS(Chinese)

 Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2

 Synthetic Route

Previous 1/8 Next

(4R,4aS,6R)-4,4... 72453-44-2 ~95% Nootkatone 4674-50-4

Literature: Sauer, Anne M.; Crowe, William E.; Henderson, Gregg; Laine, Roger A. Organic Letters, 2009 , vol. 11, # 16 p. 3530 - 3533

eremophilene 10219-75-7 ~67% phthalimide 136918-14-4 Nootkatone 4674-50-4 4α,4a&alp... 840474-83-1

Literature: Sugahara, Michihiro Patent: US2004/14985 A1, 2004 ; Location in patent: Page 9 ;

eremophilene 10219-75-7 ~82% Nootkatone 4674-50-4

Literature: Furusawa, Mai; Hashimoto, Toshihiro; Noma, Yoshiaki; Asakawa, Yoshinori Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 11 p. 1513 - 1514

 Precursor & DownStream

Precursor  10	Previous 1/3 Next
CAS#:72453-44-2 (4R,4aS,6R)-4,4...  CAS#:10219-75-7 eremophilene  CAS#:38651-65-9 Bicyclo[3.1.1]h...  CAS#:72453-38-4 (1R,3R,5R)-6,6-...
DownStream  1
CAS#:15764-04-2 alpha-vetivone

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