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Postion:Product Catalog >Flavors and fragrances>Synthetic fragrances>Ketones spices>Terpene ketone>Nootkatone
Nootkatone
  • Nootkatone
  • Nootkatone

Nootkatone NEW

Price $9 $6 $3
Package 1KG 5KG 25KG
Min. Order: 0.1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2025-06-28

Product Details

Product Name: Nootkatone CAS No.: 4674-50-4
Min. Order: 0.1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2025/06/28
Lead time: In stock, ready for shipment Packaging: 1kg,5kg,25kgs,200kgs;bulk
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Note: Hot sales

Nootkatone

Modify Date: 2024-01-02 22:30:18

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Nootkatone structure
Common NameNootkatone
CAS Number4674-50-4Molecular Weight218.335
Density1.0±0.1 g/cm3Boiling Point318.6±42.0 °C at 760 mmHg
Molecular FormulaC15H22OMelting Point35-39oC
MSDSChineseUSAFlash Point142.1±18.7 °C
SymbolArticle illustration
GHS07
Signal WordWarning




PurityQuantityBudgetInquiry

 Use of Nootkatone


Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].

 Names

Name(+)-Nootkatone
SynonymMore Synonyms

 Nootkatone Biological Activity

DescriptionNootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].
Related Catalog
Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease
In VivoNootkatone (10?mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10?mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10?mg/kg) decreased the high expression of these inflammatory cytokines[1].
References

[1]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85.

[2]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85.

 Chemical & Physical Properties

Density1.0±0.1 g/cm3
Boiling Point318.6±42.0 °C at 760 mmHg
Melting Point35-39oC
Molecular FormulaC15H22O
Molecular Weight218.335
Flash Point142.1±18.7 °C
Exact Mass218.167068
PSA17.07000
LogP3.84
Vapour Pressure0.0±0.7 mmHg at 25°C
Index of Refraction1.503
Storage condition2-8°C
StabilityStable. Incompatible with strong oxidizing agents.
Water SolubilitySlightly soluble in ethanol and chloroform. Partly soluble in water.

 MSDS

Nootkatone MSDS(Chinese)

 Safety Information

SymbolArticle illustration
GHS07
Signal WordWarning
Hazard StatementsH317
Precautionary StatementsP280
Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXi
Safety PhrasesS24/25
RIDADRNONH for all modes of transport
WGK Germany2

 Synthetic Route

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(4R,4aS,6R)-4,4...

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Nootkatone

4674-50-4

Literature: Sauer, Anne M.; Crowe, William E.; Henderson, Gregg; Laine, Roger A. Organic Letters, 2009 , vol. 11, # 16 p. 3530 - 3533
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eremophilene

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~67%

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4α,4a&alp...

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Literature: Sugahara, Michihiro Patent: US2004/14985 A1, 2004 ; Location in patent: Page 9 ;
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eremophilene

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~82%

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Nootkatone

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Literature: Furusawa, Mai; Hashimoto, Toshihiro; Noma, Yoshiaki; Asakawa, Yoshinori Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 11 p. 1513 - 1514

 Precursor & DownStream

Precursor  10

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DownStream  1


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Company Profile


    Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.


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Based on industry norms, customer requirements, and internal quality objectives, we establish clear quality standards. By monitoring the production process in real-time, we ensure that every step conforms to the predetermined quality standards.

Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.


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Our technological innovation is reflected in the development of new materials that are at the leading edge of the industry. These materials not only possess higher performance and lower costs but also enable sustainable use within an environmentally friendly production process.


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Based on rich experience in material development and production, we have established a more scientific cost control system. By ensuring product quality, and through refined management and continuous process optimization, we offer more competitive prices.


Word of mouth

Adhering to the principle of customer first, customer first, and honest service, we have established long-term business relationships with customers and are deeply welcomed and trusted by them.


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Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.

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After-sale service:

We assist buyers in customs clearance by providing necessary documents and information.

If there is any dispute over product quality, we are committed to providing the best solution.


Our packaging and shipping

? Packaging: 

1kg/bag or bottle, 25kg/drum, 50kg/drum, 200L/drum, 1T/bag or IBC drum, standard export packaging or packaging required by customers.

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Shipping

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Contact information

For more details, pls contact us freely.

Name: Elin

Email: jiuyitime@fdachem.com


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Company Profile Introduction

Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions. With our agile custom synthesis capabilities and responsive supply chain system, our products have gained widespread adoption across Asian markets including Japan, South Korea, Singapore, and Malaysia, while also expanding deeply into Europe and the Americas. We have forged long-term strategic partnerships with numerous leading global enterprises in the sector. "Driving value through technology and earning trust through service" is our core mission. Looking ahead, we will continue to focus on technological breakthroughs and green innovation in new materials, collaborating with partners to build a high-quality industrial ecosystem and provide globally competitive solutions with greater foresight.

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