
Nootkatone NEW
Price | $9 | $6 | $3 |
Package | 1KG | 5KG | 25KG |
Min. Order: | 0.1KG |
Supply Ability: | g-kg-tons, free sample is available |
Update Time: | 2025-06-28 |
Product Details
Product Name: Nootkatone | CAS No.: 4674-50-4 |
Min. Order: 0.1KG | Purity: 99% |
Supply Ability: g-kg-tons, free sample is available | Release date: 2025/06/28 |
Lead time: In stock, ready for shipment | Packaging: 1kg,5kg,25kgs,200kgs;bulk |
Delivery: By express, by air, by sea | Origin: Manufacturer, advantage product |
COA, MSDS: Available, contact us for details | Note: Hot sales |
Nootkatone
![]() Nootkatone structure | Common Name | Nootkatone | ||
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CAS Number | 4674-50-4 | Molecular Weight | 218.335 | |
Density | 1.0±0.1 g/cm3 | Boiling Point | 318.6±42.0 °C at 760 mmHg | |
Molecular Formula | C15H22O | Melting Point | 35-39oC | |
MSDS | ChineseUSA | Flash Point | 142.1±18.7 °C | |
Symbol | ![]() GHS07 | Signal Word | Warning | |
Purity | Quantity | Budget | Inquiry |
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Use of NootkatoneNootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2]. |
Name | (+)-Nootkatone |
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Synonym | More Synonyms |
Description | Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2]. |
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Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease |
In Vivo | Nootkatone (10?mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10?mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10?mg/kg) decreased the high expression of these inflammatory cytokines[1]. |
References | [1]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85. [2]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85. |
Density | 1.0±0.1 g/cm3 |
---|---|
Boiling Point | 318.6±42.0 °C at 760 mmHg |
Melting Point | 35-39oC |
Molecular Formula | C15H22O |
Molecular Weight | 218.335 |
Flash Point | 142.1±18.7 °C |
Exact Mass | 218.167068 |
PSA | 17.07000 |
LogP | 3.84 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.503 |
Storage condition | 2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Water Solubility | Slightly soluble in ethanol and chloroform. Partly soluble in water. |
Nootkatone MSDS(Chinese) |
Symbol | ![]() GHS07 |
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Signal Word | Warning |
Hazard Statements | H317 |
Precautionary Statements | P280 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
Hazard Codes | Xi |
Safety Phrases | S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
![]() (4R,4aS,6R)-4,4... 72453-44-2 ~95% ![]() Nootkatone 4674-50-4 |
Literature: Sauer, Anne M.; Crowe, William E.; Henderson, Gregg; Laine, Roger A. Organic Letters, 2009 , vol. 11, # 16 p. 3530 - 3533 |
![]() eremophilene 10219-75-7 ~67% ![]() phthalimide 136918-14-4 ![]() Nootkatone 4674-50-4 ![]() 4α,4a&alp... 840474-83-1 |
Literature: Sugahara, Michihiro Patent: US2004/14985 A1, 2004 ; Location in patent: Page 9 ; |
![]() eremophilene 10219-75-7 ~82% ![]() Nootkatone 4674-50-4 |
Literature: Furusawa, Mai; Hashimoto, Toshihiro; Noma, Yoshiaki; Asakawa, Yoshinori Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 11 p. 1513 - 1514 |
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