Product Details
| Product Name:
Nitecapone |
CAS No.:
116313-94-1 |
| Purity:
99% |
Supply Ability:
10g |
| Release date:
2025/06/22 |
Product Introduction
Bioactivity
| Name | Nitecapone |
| Description | Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver) |
| Animal Research | Used single and repeated administration of a peripherally restricted, short-acting (nitecapone) and also a centrally acting (3,5-dinitrocatechol, OR-486) COMT inhibitor.?We also tested CGP 28014, an indirect inhibitor of COMT enzyme.?Effects of OR-486 on thermal nociception were also studied in COMT deficient mice.?Effects on spinal pathways were assessed in rats given intrathecal nitecapone[2]. |
| In vitro | At high micromolar to millimolar concentrations in in vitro research studies, nitecapone is an effective antioxidant, nitric oxide radical scavenger, and iron chelator that can protect cells from lipid peroxidation[1] |
| In vivo | After single administration, both?nitecapone?and OR-486 reduced mechanical nociceptive thresholds and thermal nociceptive latencies (hot plate test) at 2 and 3 h, regardless of their brain penetration. These effects were still present after chronic treatment with COMT inhibitors for 5 days. Intraplantar injection of carrageenan reduced nociceptive latencies and both COMT inhibitors potentiated this reduction without modifying inflammation. CGP 28014 shortened paw flick latencies. OR-486 did not modify hot plate times in Comt gene deficient mice. Intrathecal?nitecapone?modified neither thermal nor mechanical nociception[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
| Solubility Information | DMSO : 2.5 mg/mL (9.43 mM), Sonication is recommended.
|
| Keywords | S-COMT | ROS | Parkinson | OR-462 | OR462 | OR 462 | Nitecapone | Inhibitor | inhibit | GSH | glutathione | COMT | allodynia |
| Inhibitors Related | Alendronate sodium trihydrate | Serotonin hydrochloride | Rosmarinic acid | Risedronate Sodium | Risedronic Acid | 3-Methoxybenzamide | Entacapone | CBHcy | Minodronic acid monohydrate | OU749 | Ibandronate sodium | Flopropione |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | ReFRAME Related Library | Anti-Parkinson's Disease Compound Library | Antioxidant Compound Library | Inhibitor Library | Orally Active Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1g |
VIP6Y
|
Career Henan Chemical Co
|
2020-02-01 |
United States