Nicotinamide N-oxide NEW
| Price | $33 | $48 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-26 |
Product Details
| Product Name: Nicotinamide N-oxide | CAS No.: 1986-81-8 |
| Purity: 99.9% | Supply Ability: 10g |
| Release date: 2025/05/26 |
Product Introduction
Bioactivity
| Name | Nicotinamide N-oxide |
| Description | Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase. |
| In vitro | Nicotinamide, a vitamin B3 variant, serves as a precursor to nicotinamide adenine dinucleotide, crucial for oxidative phosphorylation and dehydrogenase cofactor roles. It undergoes metabolism via two pathways: initial methylation by nicotinamide N-methyltransferase, followed by aldehyde oxidase oxidation, and direct oxidation to nicotinamide N-oxide. Studies have introduced a range of nicotinamide N-oxides as innovative, effective CXCR2 receptor antagonists. Specifically, Compound 1 effectively inhibits neutrophil chemotaxis (IC50=10 nM), whereas Compound 2 selectively blocks IL-8 binding (IC50=110 nM) and also significantly hampers neutrophil chemotaxis (IC50=170 nM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.85 mg/mL (27.85 mM), Sonication is recommended. H2O : Limited solubility |
| Keywords | Nicotinamide N-oxide | Nicotinamide Noxide | Nicotinamide N oxide | Nicotinamide | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | DrugMetabolite | Drug Metabolite | CXCR | CXC chemokine receptors | c-Myc | cMyc |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Gut Microbial Metabolite Library | GPCR Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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