NF-κB-IN-8 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: NF-κB-IN-8 | CAS No.: 2924565-59-1 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | NF-κB-IN-8 |
| Description | NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, including acute lung injury (ALI) [1]. |
| In vitro | NF-κB-IN-8 (compound L26) at a concentration of 10 μM inhibits 64.30% of ALP activity [1]. Additionally, within a range of 1-10 μM for 24 hours, NF-κB-IN-8 suppresses the expression of IL-6 and TNF-α in RAW 264.7 cells [1]. At concentrations spanning from 0 to 50 μM, NF-κB-IN-8 hinders the binding of LPS to MD-2, as detected by ELISA [1]. At 50 μM, administered overnight, the compound prevents the formation of the LPS/MD-2/TLR4 complex in RAW264.7 cells [1]. |
| In vivo | NF-κB-IN-8 (Compound L26), administered orally at a dose of 5 mg/kg, mitigated LPS-induced acute lung injury in mice [1]. At higher doses of 1000 and 1500 mg/kg, NF-κB-IN-8 demonstrated low toxicity and was deemed safe in mice [1]. In rats, with an administered dose of 0 mg/kg, NF-κB-IN-8 exhibited a half-life (T 1/2) of 4.2 hours and a maximum concentration (C max) of 163.288 μg/L [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | NFκB | NF-kB | NFkB |
| Inhibitors Related | Naringin dihydrochalcone | Lidocaine | Methylamine HCl | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | N,N-Dimethylacetamide | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Sodium salicylate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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