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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Neuronal Signaling>Adrenergic Receptor Inhibitors>Nebivolol hydrochloride
Nebivolol hydrochloride
  • Nebivolol hydrochloride

Nebivolol hydrochloride NEW

Price $43 $63 $97
Package 10mg 25mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-01

Product Details

Product Name: Nebivolol hydrochloride CAS No.: 152520-56-4
Purity: 99.85% Supply Ability: 10g
Release date: 2025/05/01

Product Introduction

Bioactivity

NameNebivolol hydrochloride
DescriptionNebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.
Cell ResearchCells are exposed to different concentrations of Nebivolol (10-7~10-5 M) for 1, 2, 4, 7 and 14 days. Cell proliferation is analyzed by bromodeoxyuridine (BrdU) incorporation, and cell apoptosis is detected by PI or annexin V staining.(Only for Reference)
In vitroNebivolol treatment of rats with myocardial infarction lowered mean blood pressure by a small amount. Nebivolol reduced myocardial apoptosis in rats with myocardial infarction when administered intravenously for 10 minutes followed by oral administration.
In vivoNebivolol reduced the proliferation of coronary smooth muscle cells (haCSMCs) and endothelial cells (haECs) in a concentration- and time-dependent manner.Nebivolol acted with high affinity and selectivity at the beta 1-adrenergic receptor site in the preparation of rabbit lung membranes.Nebivolol treatment of haCSMCs for 7 days significantly inhibited cell proliferation (IC50 ~ 10 μM). Nebivolol treated haCSMCs for 7 days, significantly inhibited cell proliferation (IC50: 6.1 μM). nebivolol treated haCSMCs for 48 hours, the apoptosis rate was 23%, and reduced the number of S-phase cells.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : 4.4 mg/mL (9.96 mM), Sonication is recommended.
DMSO : 60 mg/mL (135.78 mM), Sonication is recommended.
Keywordsβ1-adrenoceptor | vasodilator | R65824 | R-065824 Hydrochloride | R065824 Hydrochloride | R-065824 | R065824 | R 65824 | R 065824 Hydrochloride | R 065824 | oral | Nebivolol hydrochloride | Nebivolol Hydrochloride | Nebivolol | ischemic heart disease | Inhibitor | inhibit | hypertension | coronary artery disease | congestive heart failure | Beta Receptor | Apoptosis | AdrenergicReceptor | Adrenergic Receptor | adrenergic blocking
Inhibitors RelatedStavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Metronidazole | Sorafenib | Tributyrin | L-Ascorbic acid sodium salt | Salicylic acid
Related Compound LibrariesHighly Selective Inhibitor Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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