NB-360 NEW
| Price | $112 | $238 | $353 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-26 |
Product Details
| Product Name: NB-360 | CAS No.: 1262857-73-7 |
| Purity: 99.25% | Supply Ability: 10g |
| Release date: 2025/05/26 |
Product Introduction
Bioactivity
| Name | NB-360 |
| Description | NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D. |
| In vivo | NB-360 blocks the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. Almost complete reduction of Aβ was achieved also in rats and in dogs. NB-360 stops accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (100.13 mM), Sonication is recommended. |
| Keywords | β-Secretase | NB-360 | NB360 | NB 360 | Mouse , human BACE1 | Inhibitor | inhibit | Beta-secretase | BACE2 | BACE1 | BACE |
| Inhibitors Related | Auraptene | Verubecestat | DSS30 | LX2343 | SEW06622 | Loganin | Atabecestat | LY2886721 | Phytic acid potassium | Epiberberine | Aloeresin D | Epiberberine chloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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