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Postion:Product Catalog >N-Nitroso Clozapine
N-Nitroso Clozapine
  • N-Nitroso Clozapine
  • N-Nitroso Clozapine
  • N-Nitroso Clozapine
  • N-Nitroso Clozapine
  • N-Nitroso Clozapine

N-Nitroso Clozapine NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-15

Product Details

Product Name: N-Nitroso Clozapine CAS No.: 156632-03-0
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/15
Molecular formula: C18H18ClN5O

N-Nitroso Clozapine;156632-03-0

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WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


  • Product Information

  • Product Number: N031068

  • English Name: N-Nitroso Clozapine

  • English Alias: 8-chloro-11-(4-methylpiperazin-1-yl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine

  • CAS Number: 156632-03-0

  • Molecular Formula: C??H??ClN?O

  • Molecular Weight: 355.82

  • Advantages

  • As a nitroso derivative impurity of Clozapine, this compound has the following advantages:

  • Well-defined and distinct structure: Contains nitroso (-NO) group, dibenzo[b,e][1,4]diazepine ring, chlorine atom, and methylpiperazinyl, differing from Clozapine by nitroso substitution on the 5-position nitrogen. It can be accurately identified by techniques such as HPLC and LC-MS, providing a specific marker for impurity detection;

  • High stability and traceability: The conjugated structure of nitroso group and diazepine ring is highly stable. As a product of amino oxidation during Clozapine storage or metabolism, it directly reflects oxidative degradation, improving quality tracing accuracy;

  • High detection sensitivity: The conjugated system of nitroso group shows strong UV absorption (240-260nm), and combined with chlorine isotopic characteristics, trace analysis can be achieved via HPLC-UV or LC-MS, compatible with heterocyclic drug detection systems.

  • Applications

  • Pharmaceutical quality control: Used as an impurity reference to identify and quantify N-Nitroso Clozapine in Clozapine APIs and formulations, ensuring residual nitroso impurities meet quality standards;

  • Stability testing: Assessing oxidative stability of Clozapine formulations under light and high temperature by monitoring impurity levels to guide storage condition design;

  • Metabolic studies: Investigating in vivo oxidative metabolism of Clozapine, clarifying formation and clearance pathways of nitroso impurities to support safety evaluation.

  • Background Description

  • Clozapine is an atypical antipsychotic for treatment-resistant schizophrenia, with a structure containing dibenzo[b,e][1,4]diazepine and oxidizable amino groups. During storage (especially under air or light exposure), amino groups may oxidize to form nitroso derivatives, namely N-Nitroso Clozapine. Nitrosamines have potential genotoxicity, making their control critical for Clozapine quality assurance and safety evaluation.
  • Research Status

  • Current research focuses on:

  • Detection optimization: Using UPLC-MS/MS with chlorine isotope (3?Cl/3?Cl) and nitroso fragment monitoring to achieve ultra-trace detection (ppb level);

  • Oxidation kinetics: Studying impurity formation rates under varying pH and oxygen levels to identify key drivers of amino oxidation in Clozapine;

  • Toxicological assessment: Evaluating genotoxic potential via in vitro assays to establish strict impurity limits;

  • Stabilization strategies: Developing oxygen-impermeable packaging and antioxidant additives to minimize nitroso impurity formation in Clozapine products.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com



Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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