Product Details
| Product Name:
MDL 105519 |
CAS No.:
161230-88-2 |
| Supply Ability:
10g |
Release date:
2025/07/17 |
Product Introduction
Bioactivity
| Name | MDL 105519 |
| Description | MDL 105519 is an effective antagonist of glycine binding to the NMDA receptor. |
| In vitro | MDL 105519 is approximately 10,000-fold selective for the glycine recognition site relative to the other receptor types investigated. MDL 105519 is an effective and selective ligand for the glycine recognition site that completely inhibit the binding of [3H]glycine to rat brain membranes (Ki: 10.9 nM). MDL 105519 inhibits NMDA-dependent responses, such as elevations of [3H]TCP binding in brain membranes, cyclic GMP accumulation in brain slices, and alterations in cytosolic Ca2+ and Na+-Ca2+ currents in cultured neurons. Its inhibition is non-competitive with respect to NMDA and could be nullified with D-serine. |
| In vivo | MDL 105519 acts as an NMDA receptor antagonist in vivo, effectively blocking harmaline-induced increases in cerebellar cyclic GMP levels through intravenous administration, demonstrating its biochemical antagonistic properties. It exhibits anxiolytic effects in rat separation-induced vocalization tests, with noticeable muscle-relaxant properties at reduced dosages. The compound's antagonism also correlates with anticonvulsant effects across various seizure models, including genetic, chemically induced, and electrically provoked. Although higher doses compromise rotorod performance, they do not influence mesolimbic dopamine turnover or affect prepulse inhibition of the startle reflex. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 17 mg/mL (45.19 mM), Sonication and heating are recommended.
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| Keywords | MDL 105519 | MDL105519 | MDL-105519 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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$43.00/1mg |
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