MAO A/HSP90-IN-2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: MAO A/HSP90-IN-2 | CAS No.: 2927489-99-2 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | MAO A/HSP90-IN-2 |
| Description | MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound enhances HSP70 expression, diminishes HER2 and phospho-Akt levels, downregulates IFN-γ-induced PD-L1 expression in GL26 cells, and demonstrates efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, and non-small cell lung cancer, possibly impeding tumor immune evasion [1]. |
| In vitro | MAO A/HSP90-IN-2 inhibits the growth of murine and human glioma cells, as well as colon cancer, leukemia, and non-small cell lung cancer cells (GL26, U251S, U251R, U87MG, U373MG, and LN229, with IC50 values of 0.49, 1.09, 0.26, 0.36, 0.89, and 0.31 μM, respectively) [1]. The compound, at concentrations of 0.3 to 3 μM for 24 hours, upregulates HSP70 expression and downregulates HER2 and phosphorylated AKT expression in GL26 and U251R cells [1]. Additionally, MAO A/HSP90-IN-2, at doses of 0.5 to 1 μM over 24 hours, suppresses the IFN-γ-induced upregulation of PD-L1 in GL26 cells [1]. |
| In vivo | MAO A/HSP90-IN-2 (Compound 4-C) administered at a dose of 25mg/kg via intraperitoneal injection for 8 days demonstrated tumor growth inhibition in the GL26 xenograft tumor model [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | MonoamineOxidase | Monoamine Oxidase |
| Inhibitors Related | Norharmane | J-147 | Azure B | Iproniazid Phosphate | Paeonol | Isatin | Methylene Blue | Pargyline hydrochloride | Methylene Blue trihydrate | Phenelzine sulfate | Aminoacetone hydrochloride | Bifemelane hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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