Product Details
| Product Name:
M443 |
CAS No.:
1820684-31-8 |
| Purity:
98.95% |
Supply Ability:
10g |
| Release date:
2025/06/12 |
Product Introduction
Bioactivity
| Name | M443 |
| Description | M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research. |
| In vitro | The osmotic pumps were filled with a solution of 0.05 mg/ml M443 or vehicle [0.01% DMSO in PBS], and implanted into the backs of animals. The results showed that treatment with M443 alone extended the survival of mice by 5.5 days. |
| In vivo | As a time-dependent irreversible MRK inhibitor, M443 (500 nM) significantly inhibits the activation of MRK, Chk2, and p38 stimulated by IR. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (50.88 mM), Sonication is recommended.
|
| Keywords | p38MAPK | p38 MAPK | p38 | MRK | M-443 | M443 | M 443 | Chk2 |
| Inhibitors Related | Adezmapimod | Exarafenib | Doramapimod | Prexasertib | Bakuchiol | Asiatic acid | p38α inhibitor 3 | SB 202190 | (-)-Bornyl acetate | Baricitinib | MW-150 | Nisin Z |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States