LY-402913 NEW
| Price | $117 | $175 | $268 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-09 |
Product Details
| Product Name: LY-402913 | CAS No.: 334970-65-9 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/05/09 |
Product Introduction
Bioactivity
| Name | LY-402913 |
| Description | LY-402913 is a selective inhibitor of the multidrug resistance protein (MRP1). |
| In vitro | LY-402913 inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC50=0.90 μM), while showing no inherent cytotoxicity. LY-402913 inhibits ATP-dependent, MRP1-mediated LTC4 uptake into membrane vesicles prepared from the MRP1-overexpressing HeLa-T5 cells (EC50=1.8 μM). LY-402913 also shows selectivity (～22-fold) against the related transporter, P-glycoprotein, in HL60/Adr and HL60/Vinc cells[2]. |
| In vivo | When dosed in combination with the oncolytic MRP1 substrate vincristine, LY-402913 delays the growth of MRP1-overexpressing tumors in vivo[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (93.64 mM), Sonication is recommended. |
| Keywords | MRP1 | LY-402913 |
| Inhibitors Related | Fluoxetine | Cyclophosphamide hydrate | Prazosin hydrochloride | Prednisone | Perindopril erbumine | Cholesterol | Estriol | Benzocaine | Flurbiprofen | Cyclophosphamide | Clarithromycin | Ketoprofen |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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