Product Details
| Product Name:
Lupanine |
CAS No.:
550-90-3 |
| Supply Ability:
10g |
Release date:
2025/04/29 |
Product Introduction
Bioactivity
| Name | Lupanine |
| Description | Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes. |
| In vitro | Lupanine (0-100 μM) treats SH-SY5Y cells with EC50 and DC50 values ??of 10.7 μM and 28.2 μM, respectively. [2] |
| In vivo | Methods: Lupanine (20 mg/kg, orally) was administered to non-diabetic and diabetic rats, and an oral glucose tolerance test was performed 30 minutes later.
Results: Lupanine reduced blood glucose concentrations and improved glycemic control in an in vivo diabetic rat model. [3] |
| Storage | keep away from direct sunlight | store at 4°C | Shipping with blue ice. |
| Keywords | PotassiumChannel | Potassium Channel | Lupanine | CalciumChannel | Calcium Channel | ATPase |
| Inhibitors Related | Adiphenine hydrochloride | Minoxidil sulfate | Tannic acid | Urethane | Ribavirin | Hydrochlorothiazide | D-Menthol | Ursodeoxycholic acid | Choline chloride | Chlorzoxazone | Methyl tridecanoate | Indapamide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1320.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-07-19 |
United States