Product Details
| Product Name:
LT052 |
CAS No.:
2543545-44-2 |
| Purity:
98.87% |
Supply Ability:
10g |
| Release date:
2025/07/22 |
Product Introduction
Bioactivity
| Name | LT052 |
| Description | LT052 is a selective and efficient BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 inflammatory signaling pathway and can be used in gout arthritis research. |
| In vitro | LT052 (1 μm,1h) inhibited MSU-induced apoptosis of THP-1 cells through the BRD4/NF-κB/NLRP3 signaling pathway.
LT052 showed good inhibitory activity on NO production in RAW264.7 cells. LT052 inhibits NF-κB transcriptional activity in HUVECs.
LT052 inhibits scorch death of macrophages in rat synovial tissue by regulating the BRD4/NF-κB/NLRP3 signaling pathway. [1] |
| In vivo | LT052 has a high clearance rate in the range of 93.517 μL/min/mg proteins to 146.685 μL/min/mg proteins in liver microsomes of multiple species (human, monkey, dog, rat). Overall, LT052 exhibits moderately stable levels of in vitro liver microsomal metabolism[1].
LT052 (1 mg/kg;?intra-articular) suppresses synovial hyperplasia as well as severe neutrophil infiltration, and has a good therapeutic effect on MSU-induced acute gouty arthritis[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 5 mg/mL (11.12 mM), Sonication is recommended.
|
| Keywords | LT-052 | LT052 | EpigeneticReaderDomain | Epigenetic Reader Domain | BRPF1b | BRDT BD1 | BRD4 BD1 | BRD3 BD1 |
| Inhibitors Related | ABBV-744 | CeMMEC1 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | J-147 | Anacardic Acid | Curcumin | dBET6 | Piflufolastat | Naphthol AS-E | Bisdemethoxycurcumin | GSK1379725A |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:2366264-12-0
$1860.00 / 100mg
-
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
United States