LS-102 NEW
| Price | $50 | $118 | $180 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: LS-102 | CAS No.: 1456891-34-1 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | LS-102 |
| Description | LS-102 is a selective inhibitor of the E3 ligase synoviolin (Syvn1), an astragaloside IV derivative, which attenuates myocardial ischemia/reperfusion injury by inhibiting mitochondrial fission.LS-102 inhibits Syvn1 auto-ubiquitylation, which ameliorates amyloidazole-induced slowing of the heart rate, and is useful for studying cardiovascular diseases. |
| In vitro | In rheumatoid synovial cells (RSCs), LS-102 (20, 40, 60 μM; 12 hours) inhibited the proliferation of RSCs with an IC50 of 5.4 μM[1]. |
| In vivo | LS-102 (1.3-4 mg/kg; i.p.; daily for 4 weeks) reduces clinical severity scores in a CIA model [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL (176.76 mM), Sonication is recommended. |
| Keywords | LS-102 | LS 102 | LigandforE3Ligase | Ligand for E3 Ligase | E3 Ligase |
| Inhibitors Related | Lenalidomide-Br | Thalidomide | (S,R,S)-AHPC | Thalidomide 4-fluoride | Pomalidomide | Lenalidomide | Thalidomide-5-OH | (S,R,S)-AHPC hydrochloride | 5-Aminothalidomide | Thalidomide 5-fluoride | Thalidomide-4-OH | Thalidomide-O-COOH |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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