LP-533401 NEW
| Price | Get Latest Price | ||
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-26 |
Product Details
| Product Name: LP-533401 | CAS No.: 945976-43-2 |
| Supply Ability: 10g | Release date: 2025/07/26 |
Product Introduction
Bioactivity
| Name | LP-533401 |
| Description | LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut. |
| In vitro | At a dose of 1 μM, LP-533401 fully suppresses serotonin production in Tph1–expressing cells [1]. |
| In vivo | Mice treated repeatedly with LP-533401 (30–250 mg/kg per day) exhibit marked 5-HT content reductions in the gut, lungs, and blood, but not in the brain. Adult, healthy mice treated with the Tph-1 inhibitor LP-533401 display a 30% decrease in circulating serotonin levels, with a consequent 30% increase in osteoblast numbers. Pharmacokinetic studies in rodents show that the LP-533401 level in the brain is negligible following oral administration, indicating that it is virtually unable to cross the blood-brain barrier[1]. Lung and gut 5-HT contents decrease by 50%, after a single LP533401 dose (250 mg/kg), whereas blood 5-HT levels remain unchanged, suggesting gut and lung 5-HT synthesis[2]. Administration of LP533401 to mice injected with EL4 cells inhibits the decrement in osteoblast numbers and trabecular bone volume prolongs survial, and decreases leukemic infiltration[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Tryptophan hydroxylase | LP-533401 | LP533401 | LP 533401 |
| Inhibitors Related | p-Ethynylphenylalanine | Mildronate | Tetrahydropapaverine hydrochloride | Casein | p-Fluoro-L-phenylalanine | Telotristat Etiprate | Ketoconazole | Bupicomide | Diethyl-pythiDC | Fenclonine | Nepicastat hydrochloride | Sapropterin dihydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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