LOX-IN-3 dihydrochloride monohydrate NEW
| Price | $2140 | $2785 | $3520 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: LOX-IN-3 dihydrochloride monohydrate | CAS No.: 2414974-55-1 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | LOX-IN-3 dihydrochloride monohydrate |
| Description | LOX-IN-3 dihydrochloride monohydrate (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor, intended for research in fibrosis, cancer, and angiogenesis [1]. |
| In vitro | LOX-IN-3 dihydrochloride monohydrate (Compound 33) effectively inhibits bovine LOX and human LOXL2 with IC50 values of <10 μM and <1 μM, respectively, while maintaining prolonged inhibition of LOXL1 and LOXL2 and showing reduced activity against SSAO/VAP-1 and MAO-B [1]. |
| In vivo | LOX-IN-3 dihydrochloride monohydrate (Compound 33) administered at various doses and durations has shown effects on fibrosis and enzyme activity in animal models. A 30 mg/kg oral dose abolished lysyl oxidase activity in male Wistar rats, with plasma concentrations dropping below IC 50 after 8 hours and a recovery half-life of 2-3 days (ear) to 24 hours (aorta) [1]. Daily oral administration of 10 mg/kg for 14 days in a UUO model increased kidney weight and thickness while reducing fibrosis area in mice [1]. A daily oral dose of 15 mg/kg for 21 days significantly decreased lung fibrosis in C57Bl/6 mice, evidenced by reductions in the Ashcroft score and lung weight [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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