
Lotilaner
Price | $1 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 10000 |
Update Time: | 2025-08-01 |
Product Details
Product Name: Lotilaner | CAS No.: 1369852-71-0 |
Min. Order: 1kg | Purity: 99% |
Supply Ability: 10000 | Release date: 2025/08/01 |
IUPAC Name:Lotilaner
Molecular Formula:C??H??Cl?F??N?O?
Molecular Weight:671.63 g/mol
CAS Number:1369852-71-0
Appearance:White to off-white crystalline powder
Solubility:Practically insoluble in water; soluble in organic solvents (e.g., DMSO, ethanol)
Melting Point:~150-155°C (decomposes)
pKa:~4.5 (weakly acidic)
Storage:2-8°C (protect from light and moisture)
Pharmacological Class:Isoxazoline-class ectoparasiticide
Mechanism of Action:GABA-gated chloride channel antagonist (selective for parasites)
Therapeutic Use:Veterinary medicine: Treatment and prevention of fleas and ticks in dogs and cats.
Brand Names:Credelio? (Elanco), Xzl? (Zoetis)
Regulatory Status:FDA/EMA-approved for veterinary use (oral administration).
Parameter | Specification | Test Method | Typical Result |
---|---|---|---|
Product Name | Lotilaner | - | Complies |
CAS No. | 1369850-44-8 | - | Complies |
Batch No. | (e.g., LT-20240701) | - | (Custom) |
Manufacture Date | YYYY-MM-DD | - | (Custom) |
Expiry Date | YYYY-MM-DD | - | (Custom) |
Appearance | White to off-white powder | Visual Inspection | Off-white powder |
Assay (HPLC) | 98.0%~102.0% | HPLC (USP/EP) | 99.5% |
Related Substances | ≤1.0% (total impurities) | HPLC | 0.6% |
Water Content (KF) | ≤0.5% w/w | Karl Fischer | 0.3% |
Residue on Ignition | ≤0.1% | USP <281> | 0.05% |
Heavy Metals | ≤10 ppm (as Pb) | ICP-MS | <5 ppm |
Particle Size | 100% through 80 mesh | Sieve Analysis | Complies |
Microbial Limits | TAMC ≤1000 CFU/g, TYMC ≤100 CFU/g | USP <61> | Complies |
Residual Solvents | MeOH ≤3000 ppm, EtOH ≤5000 ppm | GC | <2000 ppm (MeOH) |
Optical Rotation | [α]2?D = -10° to -15° (c=1 in DMF) | Polarimetry | -12.5° |
Melting Point | 150~155°C (with decomposition) | DSC | 152°C (dec.) |
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