Lornoxicam NEW

Price	$5	$4	$2
Package	1kg	10kg	100kg

Min. Order:	1kg
Supply Ability:	100kg
Update Time:	2025-07-24

Product Details

Product Name: Lornoxicam	CAS No.: 70374-39-9
Min. Order: 1kg	Purity: 99%
Supply Ability: 100kg	Release date: 2025/07/24
Lead time: in stock	Packaging: bag/bottle/drum//IBC, as request
Delivery: By sea, by air, by express	Origin: Manufacturer, advantage products
COA, MSDS: Available, contact us for details	Contact: Tina

PRODUCT INFORMATION

Common Name	Lornoxicam
CAS Number	70374-39-9	Molecular Weight	371.819
Density	1.7±0.1 g/cm3	Boiling Point	N/A
Molecular Formula	C13H10ClN3O4S2	Melting Point	225-230°C (dec.)
MSDS	ChineseUSA	Flash Point	N/A
Symbol	GHS06	Signal Word	Danger

Purity		Quantity		Budget		Inquiry

Use of Lornoxicam

Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).Target: COXLornoxicam showed a balanced inhibition of COX-1/-2 exhibiting the lowest IC50 (0.005 microM/0.008 microM) of the large panel of NSAIDs tested. lornoxicam showed a marked inhibition of IL-6 formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta and IL-8 was only moderately affected [1]. Lornoxicam is effective in the treatment of patients with activated osteoarthritis; the analgesic and anti-inflammatory effects of lornoxicam are significantly superior to those of rofecoxib without inferiority in tolerability [2]. Lornoxicam was fully effective for prevention of hyperalgesia [3].

Properties
Articles33
Spectrum

Name	lornoxicam
Synonym	More Synonyms

Description	Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).Target: COXLornoxicam showed a balanced inhibition of COX-1/-2 exhibiting the lowest IC50 (0.005 microM/0.008 microM) of the large panel of NSAIDs tested. lornoxicam showed a marked inhibition of IL-6 formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta and IL-8 was only moderately affected [1]. Lornoxicam is effective in the treatment of patients with activated osteoarthritis; the analgesic and anti-inflammatory effects of lornoxicam are significantly superior to those of rofecoxib without inferiority in tolerability [2]. Lornoxicam was fully effective for prevention of hyperalgesia [3].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-1:5 nM (IC50, in cells) COX-2:45 nM (IC50, in cells)
References	[1]. Spyra S, et al. COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2017 Aug;174(16):2696-2705. [2]. Rose, P. and C. Steinhauser, Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig, 2004. 24(4): p. 227-36. [3]. Bianchi, M. and A.E. Panerai, Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res, 2002. 45(2): p. 101-5.

Density	1.7±0.1 g/cm3
Melting Point	225-230°C (dec.)
Molecular Formula	C13H10ClN3O4S2
Molecular Weight	371.819
Exact Mass	370.980133
PSA	136.22000
LogP	2.18
Index of Refraction	1.741
Storage condition	-20°C Freezer

Lornoxicam MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ9095000

CHEMICAL NAME :
2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide

CAS REGISTRY NUMBER :
70374-39-9

LAST UPDATED :
199806

DATA ITEMS CITED :
4

MOLECULAR FORMULA :
C13-H10-Cl-N3-O4-S2

MOLECULAR WEIGHT :
371.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
5730 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,61,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
58240 ug/kg/1Y-I

TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - pigmented or nucleated red blood cells Related to Chronic Data - death

REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,909,1997

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Primate - monkey

DOSE/DURATION :
42 mg/kg/6W-I

TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,465,1997

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Primate - monkey

DOSE/DURATION :
192 mg/kg/52W-I

TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion Blood - other changes Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,465,1997

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	UN 2811 6.1 / PGII
RTECS	XJ9095000
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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