Lonidamine NEW
| Price | $33 | $45 | $58 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Lonidamine | CAS No.: 50264-69-2 |
| Purity: 97.90% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Lonidamine |
| Description | Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). |
| In vitro | In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth. |
| In vivo | In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (186.82 mM), Sonication is recommended. Ethanol : 1.6 mg/mL (4.98 mM), Sonication is recommended. |
| Keywords | pulmonary fibrosis | MitochondrialMetabolism | Mitochondrial Metabolism | mitochondrial complex | Mitochondrial | lung fibrosis | Lonidamine | lactate | Inhibitor | inhibit | hexokinase | Hexokinase | H2030BrM3 | Apoptosis | AF-1890 | AF 1890 | A549 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Imeglimin hydrochloride | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | L-Glutamic acid | Metronidazole | Tributyrin | L-Ascorbic acid sodium salt | Salicylic acid |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $33.00/2mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-07-30 | |
| $33.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2025-07-30 | |
| $9.90/10g |
Shanghai Biolang Biotechnology Co., Ltd.
|
2022-02-22 | ||
| $10.00/10Kg/Bag |
Wuhan Demeikai Biotechnology Co., Ltd
|
2021-12-21 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
| $1.10/1g |
VIP5Y
|
Dideu Industries Group Limited
|
2021-07-02 | |
| $0.00/1g |
VIP5Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-06-24 | |
| $0.00/1Kg |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-04-30 | |
| $1.00/1KG |
VIP8Y
|
Career Henan Chemical Co
|
2018-08-20 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY