Lipoxin A4 NEW
| Price | $899 |
| Package | 25μg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-15 |
Product Details
| Product Name: Lipoxin A4 | CAS No.: 89663-86-5 |
| Purity: 95% | Supply Ability: 10g |
| Release date: 2025/05/15 |
Product Introduction
Bioactivity
| Name | Lipoxin A4 |
| Description | Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation. |
| In vitro | Lipoxin A4 (LXA4; NHEKs) inhibits the expression of IL-6 and IL-8, downregulates the expression of cyclin D1, and suppresses the ERK1/2 phosphorylation and NF-kB-p65 nuclear translocation in NHEKs.[2] Lipoxin A4 (100 nM; preincubation for 30 minutes; NHEKs) inhibits the NHEKs proliferation with or without stimulating by LPS (10 μg/mL).[2] Lipoxin A4 (100? nM; preincubation for 30 minutes) downregulates the LPS-induced secretion and expression of HMGB1 in keratinocytes.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | PBS (pH 7.2) : 0.05 mg/mL (0.14 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble.) Ethanol : 30 mg/mL (85.11 mM), Sonication is recommended. |
| Keywords | LXA-4 | LXA 4 | Lipoxin A-4 | Lipoxin A4 | Interleukin Related | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Oleamide | Glycerol | Thymidine | Naringin | L-Ascorbic acid sodium salt | 3-Indoleacetic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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