Product Details
| Product Name:
Lenumlostat |
CAS No.:
2098884-52-5 |
| Purity:
99.88% |
Supply Ability:
10g |
| Release date:
2025/07/23 |
Product Introduction
Bioactivity
| Name | Lenumlostat |
| Description | Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases. |
| In vitro | Lenumlostat(PAT-1251)is a Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 μM and 1.17 μM for hLOXL2 and hLOXL3, respectively. It also potently inhibits LOXL2 in mouse, rat, and dog, with IC50s of 0.10 μM, 0.12 μM, and 0.16 μM, respectively. Lenumlostat(PAT-1251) exhibits high selectivity for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO). Additionally, it shows selectivity against the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with less than 10% inhibition at 10 μM[1]. |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (112.69 mM), Sonication is recommended.
H2O : 80 mg/mL (200.33 mM), Sonication is recommended.
|
| Keywords | MonoamineOxidase | Monoamine Oxidase | LOXL2 |
| Inhibitors Related | Norharmane | J-147 | Azure B | Iproniazid Phosphate | Paeonol | Isatin | Methylene Blue | Pargyline hydrochloride | Methylene Blue trihydrate | Phenelzine sulfate | Aminoacetone hydrochloride | Bifemelane hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Mitochondria-Targeted Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States