Product Details
| Product Name:
Lactacystin |
CAS No.:
133343-34-7 |
| Supply Ability:
10g |
Release date:
2025/06/25 |
Product Introduction
Bioactivity
| Name | Lactacystin |
| Description | Lactacystin is a natural non-peptide proteasome inhibitor and highly specific anticancer drug that controls the UPS of cellular protein turnover and inhibits alkaline cell proliferation, and is able to be used as a model for studying dementia, induces neurite outgrowth and transiently elevated levels of cAMP, inhibits angiogenesis, triggers apoptosis in glioma cells, and can penetrate the blood-brain barrier (BBB). |
| In vitro | Methods: RA-differentiated SH-SY5Y cells were treated with lactacystin (2.5–10 μg/ml, 48 hours) to select the effective concentration for celastrol studies.
Results: Lactacystin at a concentration of 10 μg/ml (26.4 μM) reduced SH-SY5Y cell viability by 40-50%. [3] |
| In vivo | Methods: Lactacystin (5 μg/2 μl) was administered unilaterally into the left SNc of rats to study its effect on rat body weight.
Results: Lactacystin can reduce the body weight of rats. [3] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 18 mg/mL (47.82 mM), Sonication and heating are recommended.
|
| Keywords | proteasome | Lactacystin |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1g |
VIP6Y
|
Career Henan Chemical Co
|
2020-01-10 |
United States