Product Details
| Product Name:
L748337 |
CAS No.:
244192-94-7 |
| Purity:
99.67% |
Supply Ability:
10g |
| Release date:
2025/06/26 |
Product Introduction
Bioactivity
| Name | L748337 |
| Description | L748337 is a competitive and potent β3-adrenoceptor antagonist that inhibits the action of β3-, β2-, and β1-adrenoceptors, activates MAPK signaling, promotes phosphorylation of Erk1/2, and inhibits the protective effects of CL316243, and is used in the study of disorders caused by abnormalities of the β3-adrenoceptors. |
| In vitro | The β3-adrenergic receptor selective antagonist L748337 (100nM) partially antagonized the relaxation induced by (-)-isoprenaline in cav-1KO arteries, but did not antagonize the relaxation in WT arteries[1]. |
| In vivo | L748337 (5 mg/kg) exhibits anti-cancer effects in male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cells[1]. |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 20 mg/mL (40.19 mM), Sonication is recommended.
DMSO : 80 mg/mL (160.77 mM), Sonication is recommended.
|
| Keywords | β3-adrenergic receptor | β2-adrenergic receptor | β1-adrenergic receptor | L-748337 | L748337 | L 748337 | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Olanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Amitriptyline hydrochloride | Isoprenaline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:2380273-75-4
$90.00 / 5mg
-
CAS:63302-99-8
$37.00 / 10mg
-
CAS:73069-28-0
$0.00 / 1removed
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States