午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >L48H37
L48H37
  • L48H37

L48H37 NEW

Price $64 $97 $197
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-18

Product Details

Product Name: L48H37 CAS No.: 343307-76-6
Purity: 98.42% Supply Ability: 10g
Release date: 2025/07/18

Product Introduction

Bioactivity

NameL48H37
DescriptionL48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is primarily utilized in sepsis and lung injury research [1].
In vitroL48H37 effectively suppresses LPS-induced inflammation in mouse macrophages, particularly diminishing TNF-α and IL-6 production and gene expression [1]. It also demonstrates noteworthy anticancer activity by reducing the viability of A549 and H460 lung cancer cells with IC50 values of 5.3 μM and 2.3 μM, respectively, outperforming curcumin. Importantly, its cytotoxicity towards normal human lung epithelial cells (BEAS-2B) remains low, with an IC50 of 21 μM [2]. Moreover, L48H37 at concentrations of 1, 2, or 4 μM over 16 hours decreases p-Cdc2 and Cdc2 levels, increases p53, enhances cleaved poly (ADP-ribosyl) polymerase (PARP) levels, and reduces anti-apoptotic protein Bcl-2 expression in both H460 and A549 cells, indicating apoptosis induction. Additionally, at 4 μM for 16 hours, L48H37 dose-dependently elevates intracellular ROS levels, as evidenced by increased DCF levels in these cells [2]. Cell viability assays and Western Blot analysis confirm its concentration-dependent efficacy in inhibiting lung cancer cell growth and modulating key proteins involved in cell cycle and apoptosis [2].
In vivoL48H37, administered via intraperitoneal injection at doses of 5 mg or 10 mg/kg once daily for 11 days, effectively inhibits the growth of H460 xenograft tumors and demonstrates significant anti-tumor effects in mice. This study utilized 5-week-old athymic BALB/cA nu/nu female mice weighing 18-22 g. The treatment resulted in reduced tumor wet weights compared to the control group, decreased levels of phosphorylated STAT3, and increased levels of phosphorylated EIF2α and ATF4, indicating a potent anti-tumor response without causing significant structural alterations in the mice.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 45 mg/mL (93.06 mM), Sonication is recommended.
KeywordsToll-like Receptor (TLR) | TNF-α | TLR4/MD2 | Sepsis | lung injury | LPS-TLR4/MD2 | L-48H37 | L48H37 | Inhibitor | inhibit | Inflammation | IL-6 | Curcumin | Asthma
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Pyroptosis Compound Library | Inhibitor Library | PPI Inhibitor Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$/
Anhui Ruihan Technology Co., Ltd
2023-08-21
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY