PRODUCT INFORMATION

• Properties

• Articles8

• Spectrum

 Names

Name	L-Homocystine
Synonym	More Synonyms

 L-Homocystine Biological Activity

Description	L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
Related Catalog	Natural Products >> Others Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vivo	A single or multiple doses of L-Homocystine administered to mice during organogenesis can aggravate the developmental disturbances caused by a single dose of VPA administered on GD 8. Whereas, VPA lowers significantly plasma FA and vitamin B12 concentrations, it has no direct impact on the homocysteine concentrations. Therefore, it is proposed that high levels of homocysteine disturb the FA, vitamin B12, and possibly methionine metabolism thus providing a favorable situation for VPA to interfere with the development of susceptible embryos[1].
Animal Admin	Mice[1] Groups of mice are first injected on GD 8 with a single dose of 75 mg/kg of L-Homocystine or an equal volume of saline. One half of the L-Homocystine-treated animals then receive a single dose of 600 mg/kg of VPA ((H-HoCys-OH)2+VPA group), while the other half are injected with a proportionate volume of saline (L-Homocystine+saline group). In the other experiment, mice are treated with a daily dose of 75 mg/kg of L-Homocystine or a proportionate volume of saline starting from GD 5 and continue through GD 10. One half of the L-Homocystine-treated animals also have a single exposure to 600 mg/kg of VPA (L-Homocystine+VPA group) or a proportionate volume of saline (L-Homocystine+saline group) on GD 8. The total volume of fluid injected corresponded to the body weight and does not exceed 0.45 mL[1].
References	[1]. Padmanabhan R, et al. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Eur J Nutr. 2006 Sep;45(6):311-9

 Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	507.6±50.0 °C at 760 mmHg
Melting Point	281-284oC (dec.)
Molecular Formula	C8H16N2O4S2
Molecular Weight	268.354
Flash Point	260.8±30.1 °C
Exact Mass	268.055145
PSA	177.24000
LogP	1.03
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.619
Storage condition	2~8°C

 MSDS

L-Homocystine MSDS(Chinese)

 Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

 Synthetic Route

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DL-Homocysteine CAS#:6027-13-0 ~94% L-Homocystine CAS#:626-72-2

Literature: Miyazaki, Hideya; Ohta, Atsushi; Kawakatsu, Nobuyuki; Waki, Yukitaka; Gogun, Yasuhiro; et al. Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 2 p. 536 - 540

2-amino-4-benzy... CAS#:7689-60-3 ~% L-Homocystine CAS#:626-72-2

Literature: Biochemical Preparations, , vol. 5, p. 96 Journal of Biological Chemistry, , vol. 109, p. 97,101

DL-Homocysteine CAS#:6027-13-0 N5-((R)-3-(((S)... CAS#:75027-08-6 ~% L-Homocystine CAS#:626-72-2 Glutathione CAS#:70-18-8

Literature: Journal of Organic Chemistry, , vol. 57, # 1 p. 123 - 127

 Precursor & DownStream

Precursor  4
CAS#:6027-13-0 DL-Homocysteine  CAS#:7689-60-3 2-amino-4-benzy...  CAS#:75027-08-6 N5-((R)-3-(((S)...  CAS#:139427-42-2 L-Homocysteine,...
DownStream  10	Previous 1/3 Next
CAS#:14857-77-3 L-2-AMINO-4-SUL...  CAS#:63-68-3 L-Methionine  CAS#:979-92-0 SAH  CAS#:6027-13-0 DL-Homocysteine

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