L-BUTHIONINE-(S,R)-SULFOXIMINE NEW
| Price | $33 | $47 | $80 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-07 |
Product Details
| Product Name: L-BUTHIONINE-(S,R)-SULFOXIMINE | CAS No.: 83730-53-4 |
| Purity: 99.73% | Supply Ability: 10g |
| Release date: 2025/07/07 |
Product Introduction
Bioactivity
| Name | L-BUTHIONINE-(S,R)-SULFOXIMINE |
| Description | L-Buthionine-(S,R)-sulfoximine, a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), induces oxidative stress in cells by depleting GSH. |
| In vitro | IC50 values (microM) for L-buthionine-S,R-sulfoximine (BSO) on melanoma, breast and ovarian tumor specimens were 1.9, 8.6, and 29, respectively. The IC90 for melanoma was 25.5 microM, a level 20-fold lower than steady-state levels achieved clinically [1]. GSH loss induced by L-buthionine-S,R-sulfoximine (BSO) leads to overproduction of reactive oxygen species (ROS) and triggers apoptosis of MYCN-amplified neuroblastoma cells [2]. |
| In vivo | Systemic BSO administration selectively altered GSH homeostasis and EAAT3 levels in the mice cerebellum. Intraperitoneal treatment of mice with 6?mmol/kg of BSO depleted GSH and GSSG in the liver at 2?h of treatment [3]. |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
| Solubility Information | DMSO : Insoluble H2O : 50 mg/mL (224.91 mM), Sonication is recommended. |
| Keywords | γ-glutamylcysteine synthetase | stress | oxidative | L-BUTHIONINE-SULFOXIMINE | LBUTHIONINE(S,R)SULFOXIMINE | L-Buthionine sulfoximine | L-BSO | L BUTHIONINE (S,R) SULFOXIMINE | Inhibitor | inhibit | GSH | glutamylcysteine | Ferroptosis | eye-spot | BSO |
| Inhibitors Related | TBHQ | Rosiglitazone | α-Vitamin E | L-Glutamic acid | Sorafenib | L-Glutathione reduced | Curcumin | Gallic Acid Monohydrate | L-Cystine | L-Glutamine | L-Glutamic acid monosodium salt | Cisplatin |
| Related Compound Libraries | Apoptosis Compound Library | Ferroptosis Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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