JTT 551 NEW
| Price | $1970 | $2580 | $3400 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-29 |
Product Details
| Product Name: JTT 551 | CAS No.: 776309-04-7 |
| Supply Ability: 10g | Release date: 2025/07/29 |
Product Introduction
Bioactivity
| Name | JTT 551 |
| Description | JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. |
| In vitro | JTT-551 exhibits low affinity for CD45 protein tyrosine phosphatase (CD45) and leucocyte common antigen-related (LAR) protein tyrosine phosphatase, with dissociation constants (Kis) greater than 30 μM for both. Simultaneously, it enhances insulin-induced deoxyglucose uptake in a dose-dependent manner at concentrations of 10 and 30 μM. Primarily, JTT-551 acts as a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating Kis of 0.22 μM for PTP1B and 9.3 μM for T-cell protein tyrosine phosphatase (TCPTP), thereby indicating its specificity and potential therapeutic utility in modulating insulin sensitivity. |
| In vivo | JTT 551 effectively lowers triglyceride (TG) levels at a dosage of 30 mg/kg by Day 7, without impacting insulin and total cholesterol (TC) levels. Additionally, at dosages of 3 mg/kg and 30 mg/kg administered orally (p.o.), this compound demonstrates a dose-dependent reduction in blood glucose levels in db/db mice across multiple time points, specifically on Days 7, 14, and 28. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | TCPTP | PTP1B | JTT-551 | JTT551 | JTT 551 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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