
JTP 0819958 - HOIPIN-1 NEW
Price | $63 | $102 | $233 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2025-07-09 |
Product Details
Product Name: JTP 0819958 - HOIPIN-1 | CAS No.: 2470242-33-0 |
Purity: 99.95% | Supply Ability: 10g |
Release date: 2025/07/09 |
Product Introduction
Bioactivity
Name | JTP 0819958 - HOIPIN-1 |
Description | JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2]. |
In vitro | JTP-0819958 inhibited the linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex, and the HOIP/SHARPIN complex equally, with IC50 values of 4.4, 3.5, and 3.7μM. The inhibitory effects of JTP-0819958 on LUBAC-mediated linear ubiquitin generation and inflammatory cytokine-induced NF-κB activation were confirmed in cellular levels. |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
Solubility Information | DMSO : 3.04 mg/mL (10 mM), Sonication is recommended. |
Keywords | JTP 0819958 - HOIPIN-1 | JTP 0819958 HOIPIN1 | JTP 0819958 HOIPIN 1 | IκB | IKK | IkB/IKK | IkB |
Inhibitors Related | WS3 | Amlexanox | Malachite green oxalate | Rosmarinic acid | SC-514 | Resveratrol | Bardoxolone Methyl | GSK8612 | BX795 | CCCP | Allicin | Vinpocetine |
Related Compound Libraries | Bioactive Compound Library | Ubiquitination Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Pyroptosis Compound Library | Inhibitor Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Liver Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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