JHU-083 NEW
| Price | $1520 | $1960 | $2480 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-09 |
Product Details
| Product Name: JHU-083 | CAS No.: 1998725-11-3 |
| Purity: 98.24% | Supply Ability: 10g |
| Release date: 2025/07/09 |
Product Introduction
Bioactivity
| Name | JHU-083 |
| Description | JHU-083 is an orally available, blood-brain barrier-crossing, selective glutaminase antagonist that improves cognitive performance and normalizes abnormal hippocampal glutaminase activity in APOE4 mice. |
| In vivo | JHU-083 (1.82 mg/kg; orally; every other day for 12 days) was able to alleviate CSDS-induced social avoidance behaviors as well as behaviors resembling pleasure deprivation. JHU-083 (1.82 mg/kg; orally) reduced the magnitude of CSDS-induced enhancement of glutaminase activity in CD11b+ cells in the prefrontal cortex and hippocampus, but had no significant effect on cerebellar enzyme activity. In addition, JHU-083 treatment down-regulated the CSDS-induced expression levels of IL-1β and TNF-α. [1] |
| Storage | keep away from moisture,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | PBS (pH 7.2) : 20 mg/mL (64.03 mM), Sonication is recommended. DMSO : 80 mg/mL (256.11 mM), Sonication is recommended. Ethanol : 120 mg/mL (384.16 mM), Sonication is recommended. H2O : 30 mg/mL (96.04 mM), Sonication is recommended. |
| Keywords | JHU-083 | JHU 083 | Glutamine |
| Inhibitors Related | Olmesartan Medoxomil | Losartan potassium | Tranilast | Enalapril Maleate | Azilsartan Methyl Ester | Sacubitril/Valsartan | Azilsartan | Irbesartan | Losartan | Ramipril | Captopril | Valsartan Methyl Ester |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $64.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
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2025-07-16 | |
| $10.00/1g |
Shijiazhuang Saixin Technology Co., Ltd.
|
2023-09-12 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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