
Jagged-1 (188-204) TFA(219127-21-6 free base) NEW
Price | $235 | $412 | $613 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2025-07-20 |
Product Details
Product Name: Jagged-1 (188-204) TFA(219127-21-6 free base) | Purity: 99.48% |
Supply Ability: 10g | Release date: 2025/07/20 |
Product Introduction
Bioactivity
Name | Jagged-1 (188-204) TFA(219127-21-6 free base) |
Description | Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-alphaB activation. |
In vitro | Jagged-1 (188-204) TFA (40 μM, 72 h) activates the Notch signaling pathway and induces fully differentiated maturation of human keratinocytes via NF-kappaB and PPARgamma. [2] Jagged-1 (188-204) TFA (50 μM, 24 h) enhances store-operated Ca2+ inward flow in human pulmonary artery smooth muscle cells. [3] |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | H2O : 45 mg/mL (20.26 mM), Sonication is recommended. |
Keywords | Notch | Jagged1 (188204) TFA(219127216 free base) | Jagged-1 TFA(219127-21-6 free base) | Jagged-1 TFA | Jagged-1 | Jagged 1 (188 204) TFA(219127 21 6 free base) | Gammasecretase |
Inhibitors Related | Valproic acid sodium salt | Aβ42-IN-2 | Tangeretin | gamma-secretase modulator 1 | FLI-06 | Valproic Acid | CB-103 | Gossypolone | IMR-1A | Carvacrol | RO7185876 | DAPT |
Related Compound Libraries | Neural Regeneration Compound Library | Anti-Neurodegenerative Disease Compound Library | Peptide Compound Library | NO PAINS Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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