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Postion:Product Catalog >Izuforant
Izuforant
  • Izuforant

Izuforant NEW

Price $1520 $1980 $2500
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-17

Product Details

Product Name: Izuforant CAS No.: 1429374-83-3
Supply Ability: 10g Release date: 2025/07/17

Product Introduction

Bioactivity

NameIzuforant
DescriptionIzuforant (JW1601) (Compound 24) exhibits potent anti-inflammatory and anti-pruritic activities, with a binding affinity for human serotonin 3 receptor (h5-HT3R) and an IC50 value of 9.1 μM. It is also an orally active antagonist of histamine H4 receptor (H4R), showing an IC50 value of 36 nM against human H4R [1] [2].
In vitroIzuforant (JW1601) (Compound 24) exhibits metabolic stability, with clearance rates (CL h,int) of 3.05 mL/min/mg in mice and 1.33 mL/min/mg in humans, indicating efficient metabolism across these species [1].
In vivoIzuforant (JW1601) administered orally at a dosage of 50 mg/kg once, effectively mitigates histamine-and substance P-induced itching in mice, while a higher dose of 100 mg/kg given twice daily for three weeks successfully attenuates oxazolone-induced atopic dermatitis in mice, demonstrating a 51.2% inhibition rate. This is observed in studies involving female ICR and Balb/c mice specifically aged 8 weeks and 6 weeks respectively, weighing 20±3 g. Additionally, pharmacokinetic analysis in both ICR mice and SD rats, with doses respective to their species (50 mg/kg for mice, 10 mg/kg for rats), reveals the compound's absorption and elimination profiles, marked by its half-life, maximum concentration (Cmax), and area under the curve (AUCinf), thus indicating the compound's effective duration and exposure in the body.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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