Product Details
| Product Name:
Itanapraced |
CAS No.:
749269-83-8 |
| Purity:
98% |
Supply Ability:
10g |
| Release date:
2025/07/12 |
Product Introduction
Bioactivity
| Name | Itanapraced |
| Description | Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM). |
| Kinase Assay | GSK-3β activity assay: IC50 of new synthesised compound IM-12 to GSK-3β is determined by a luminometric GSK-3β activity assay. Briefly, compounds are tested in different concentrations diluted in assay buffer containing final concentrations of: 4 mM MOPS pH 7.2; 0.4 mM EDTA; 1 mM EGTA; 2.5 mM β-glycerophosphate; 4 mM MgCl2; 40 μM BSA; 0.05 mM DTT. Four microlitres of diluted compounds are added to 25 μM pGS-2 peptide substrate, 20 ng recombinant GSK-3β and 1 μM ATP to a total assay volume of 40 μl. The enzymatic reaction is stopped after 30 min of incubation at 30 °C by adding 40 μl KinaseGlo. The luminometric signal is allowed to stabilise for 10 min and the measured with a Glomax? 96 Microplate Luminometer. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (153.77 mM), Sonication is recommended.
|
| Keywords | γ-secretase | γ secretase | βAmyloid | β Amyloid | Itanapraced | Inhibitor | inhibit | Gammasecretase | Gamma secretase | CSP1103 | CSP 1103 | CHF-5074 | CHF 5074 | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid |
| Inhibitors Related | Anle138b | Notoginsenoside R1 | Geniposide | Valproic acid sodium salt | Deferoxamine Mesylate | Tramiprosate | Dihydroergocristine mesylate | Rutin | Valproic Acid | CB-103 | Carvacrol | Methyl tridecanoate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | ReFRAME Related Library | Protease Inhibitor Library | Anti-Parkinson's Disease Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States