ISRIB (trans-isomer) NEW
| Price | $31 | $41 | $66 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-25 |
Product Details
| Product Name: ISRIB (trans-isomer) | CAS No.: 1597403-47-8 |
| Purity: 98.81% | Supply Ability: 10g |
| Release date: 2025/07/25 |
Product Introduction
Bioactivity
| Name | ISRIB (trans-isomer) |
| Description | ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2α. |
| Cell Research | U2OS cells are plated on 96-well plates and left to recover overnight. Cells are treated with either with 2 μg/ml tunicamycin or 100 nM thapsigargin in the presence or absence of 100 nM ISRIB or with ISRIB alone for the indicated and the level of eIF2α phosphorylation is determined[1]. |
| In vitro | METHODS: HEK293T cells were treated with clindamycin (2 μg/mL) to induce ER stress and with ISRIB (trans-isomer) or ISRIB (cis-isomer) (0-1 μM) for 7 h. The ATF4 fluorokinase reporter gene was detected. RESULTS: ISRIB (trans-isomer) was 100-fold more potent (IC50=5 nM) than ISRIB (cis-isomer) (IC50=600 nM), suggesting that the compound interacts stereospecifically with its cellular target. [1] METHODS: HEK293T cells were treated with Tm (1 μg/mL) and ISRIB (200 nM) for 1 h. Translation and mRNA changes were detected. RESULTS: ISRIB completely blocked the translational changes that occurred under ER stress. A large number of genes with significant changes in expression upon stress collapsed to the center of the graph under ISRIB and Tm co-treatment. [2] |
| In vivo | METHODS: To investigate the effects on memory, ISRIB (0.25-2.5 mg/kg) was administered intraperitoneally to CD-1 mice. RESULTS: ISRIB-treated mice showed significant enhancement in spatial and fear-related learning. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 0.11 mg/mL (0.24 mM), Solution. DMSO : 1.11 mg/mL (2.46 mM), Sonication is recommended. |
| Keywords | Protein kinase R-like endoplasmic reticulum kinase | PKR-like endoplasmic reticulum kinase | PERK | ISRIB (trans-isomer) | ISRIB (transisomer) | ISRIB (trans isomer) | Autophagy | Apoptosis |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Paeonol | Naringin | L-Ascorbic acid sodium salt | Alginic acid | Gefitinib |
| Related Compound Libraries | Highly Selective Inhibitor Library | Apoptosis Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Endoplasmic Reticulum Stress Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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