IR813

Modify Date: 2024-01-07 17:52:57

IR813 structure	Common Name	IR813
	CAS Number	134127-48-3	Molecular Weight	755.40600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C47H47ClN2O3S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Purity		Quantity		Budget		Inquiry

Use of IR813 IR 813 tosylate is a near-infrared (NIR) fluorescent dye (λex=815 nm, λem=840 nm) and can be used for visualizing regional lymph nodes in mice[1].

• Properties

• Spectrum

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 Names

Name	1h-benz[e]indolium, 2-[2-[2-chloro-3-[(1,3-dihydro-1,1,3-trimethyl-2h-benz[e]indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-1,1,3-trimethyl-, salt with 4-methylbenzenesulfonic acid (1:1)
Synonym	More Synonyms

 IR813 Biological Activity

Description	IR 813 tosylate is a near-infrared (NIR) fluorescent dye (λex=815 nm, λem=840 nm) and can be used for visualizing regional lymph nodes in mice[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	IR 813 (17.3 μM, 2 h) tosylate induces a 31.4% hemolysis in red blood cells[1]. IR 813 (5.9 μM, 24 h) tosylate induces 50% cell death in MRC-5 cells[1].
In Vivo	IR 813 tosylate displays a maximum fluorescence intensity at 4 h postinjection together with a rapid extravasation, when being used for visualizing regional lymph nodes in mice[1]. Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[1]. 1. Animal: Ten-week-old female Balb/cOlaAnN mice are kept in a 12 h light/dark cycle to reduce tissue autofluorescence in the NIR region, and had access to food and water ad libitum. 2. Dose: A single dose 5.1 nmol of IR 813 dye (20 μL of 0.173 mg/mL, dissolved in a PEG-400/ethanol/water=3:2:5, v/v/v solution) is subcutaneous injected in the right anterior paw of mice. 3. Imaging: Using the Fluobeam700 NIR imaging system to perform in vivo optical imaging (739 nm excitation light (3.5 mW), 750 nm long-pass emission cutoff filter).Fluorescence intensity in the axillary lymph node (ALN) is recorded for 1 week (5 min, 1 h, 4 h, 24 h, 7 days). 4. Data analysis: Semiquantitative data is obtained from the fluorescence images using ImageJ 1.44 software.

 Chemical & Physical Properties

Molecular Formula	C47H47ClN2O3S
Molecular Weight	755.40600
Exact Mass	754.30000
PSA	71.83000
LogP	12.47360

 MSDS

IR813 MSDS(Chinese)

 Synthetic Route

Total: 1 Page

4-methylbenzene... CAS#:141914-99-0 N-[(3-(Anilinom... CAS#:63857-00-1 ~81% IR813 CAS#:134127-48-3

Literature: EASTMAN KODAK COMPANY; WIDZINSKI, Thomas, J.; PAWLIK, Thomas, D.; OLM, Myra, Toffolon; BOSE, Judith, A. Patent: WO2013/55640 A2, 2013 ; Location in patent: Page/Page column 25 ;

 Precursor & DownStream

Precursor  2
CAS#:141914-99-0 4-methylbenzene...  CAS#:63857-00-1 N-[(3-(Anilinom...
DownStream

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