Ionomycin calcium NEW
| Price | $127 | Get Latest Price |
| Package | 1mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-13 |
Product Details
| Product Name: Ionomycin calcium | CAS No.: 56092-82-1 |
| Purity: 98.11% | Supply Ability: 10g |
| Release date: 2025/06/13 |
Product Introduction
Bioactivity
| Name | Ionomycin calcium |
| Description | Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, demonstrating high specificity for divalent cations (Ca>Mg>Sr=Ba). |
| In vitro | METHODS: N1E-115 cells were treated with Ionomycin calcium (0.2-10 μM) for 3-24 h. Cell viability was determined by trypan blue dye exclusion assay. RESULTS: Ionomycin calcium induced cell death in a concentration- and time-dependent manner. [1] METHODS: Fura-2-loaded mouse cerebellar astrocytes were treated with Ionomycin calcium (0.1-10 μM) for 35 min, and cell membrane Ca(2+) concentration was monitored by changes in the Fura-2 340/380 ratio. RESULTS: With Ionomycin calcium concentrations <1 μM, Ca(2+) declined slowly after an initial peak and reached a significantly lower level after 35 min. The peak Ca(2+) was maintained at a plateau stage with 2 μM Ionomycin calcium. Ionomycin calcium Ca(2+) at concentrations >2 μM was significantly higher than the initial peak after 35 min. [2] |
| In vivo | METHODS: To investigate the mechanism of demyelination induced in vivo, Ionomycin calcium (2-50 μM, 0.5 μL) was dorsal column injected into SD rats. RESULTS: Ionomycin calcium-injected rats showed varying degrees of lesions observed on days 1-21, including areas of localized edema, a few scattered demyelinated axons, and larger lesions containing up to 200 demyelinated or degenerated axons. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
| Solubility Information | DMSO : 9 mg/mL (12.05 mM), Sonication is recommended. |
| Keywords | SQ-23377 | SQ23377 | SQ 23377 | Protein kinase C | PKC | ionophore | Ionomycin calcium | Ionomycin | Inhibitor | inhibit | exosome | cleavage | CalciumChannel | Calcium ionophore | Calcium Channel | calcium | Ca2+ channels | Ca channels | Bacterial | Apoptosis | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Stavudine | Cysteamine hydrochloride | Ampicillin sodium | Kanamycin sulfate | Dextran sulfate sodium salt (MW 4500-5500) | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Tributyrin | Dimethyl sulfoxide | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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