Product Details
| Product Name:
IMB-808 |
CAS No.:
870768-70-0 |
| Purity:
99.93% |
Supply Ability:
10g |
| Release date:
2025/07/10 |
Product Introduction
Bioactivity
| Name | IMB-808 |
| Description | IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux without inducing lipidogenesis in HepG2 cells. IMB-808 can be used in atherosclerosis research. |
| In vitro | IMB-808 exhibited a significant dose-dependent effect in the concentration range of 0.001 μM to 30 μM by activating LXRβ with an EC50 of 0.53 μM. In addition, IMB-808 was able to activate LXRα in a dose-dependent manner in a luciferase reporter gene assay with the GAL4-pGL4-luc reporter plasmid with an EC50 of 0.15 μM. M.[1]
IMB-808 (0 μM-10 μM; 18 hours) significantly increased the protein and mRNA levels of ABCG1 and ABCA1 in RAW264.7 macrophage. [1]
IMB-808 (0.1 μM-10 μM; 24 h) enhanced cholesterol efflux capacity in a dose-dependent manner while decreasing cellular cholesterol concentration in cell lines. [1] |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (525.87 mM), Sonication is recommended.
|
| Keywords | IMB-808 | IMB 808 |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Doxycycline (hyclate) | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Penicillin G potassium | Doxycycline hydrochloride | Ethyl acetoacetate |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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