Idoxifene NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-16 |
Product Details
| Product Name: Idoxifene | CAS No.: 116057-75-1 |
| Supply Ability: 10g | Release date: 2025/07/16 |
Product Introduction
Bioactivity
| Name | Idoxifene |
| Description | Idoxifene is a tissue-specific selective estrogen receptor modulator. |
| In vitro | Idoxifene functions as an estrogen agonist in osteoblasts within the bone, while exhibiting minimal agonist activity in human endometrial cells. It, alongside E2, shields hepatocytes from damage caused by inflammatory cells through the inhibition of NF-κB, a proinflammatory transcription factor [2]. Additionally, Idoxifene safeguards vascular smooth muscle cells by mitigating the production of reactive oxygen species triggered by angiotensin II. It also notably reduces hepatic stellate cell (HSC) activation, curtails the proliferation of culture-activated HSCs in a dose-dependent manner, and promotes the apoptosis of these cells over time [1]. |
| In vivo | Idoxifene at doses of over 0.1 mg/kg significantly reduces the hepatic levels of collagen and MDA in the DMN model in a dose-dependent manner. Animals receive daily intraperitoneal injections of Estradiol (0.5 mg/kg) and an oral gavage of Idoxifene (0.02, 0.1, and 0.5 mg/kg) for 3 days after Dimethylnitrosamine (DMN) treatment. Although Idoxifene and E2 are administered by different routes, i.e., by oral ingestion and intraperitoneal injection, respectively. However, the antifibrotic effect of a dose of 0.5 mg/kg of Idoxifene is somewhat greater than that of the same dose of E2 [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Idoxifene | Estrogen receptor | CB-7432 | CB 7432 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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