Ibutilide NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Ibutilide | CAS No.: 122647-31-8 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Ibutilide |
| Description | Ibutilide (U70226E free base) is a potent antiarrhythmic compound that extends the action potential duration. It effectively blocks the rapidly activating delayed rectifier potassium current (I Kr ) in AT-1 cells [1]. |
| In vitro | Ibutilide is a potent IKr blocker with EC 50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells [1]. Ibutilide blocks I Kr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC 50 : 22.5±0.9 vs 27.4±2.5 nM). However, cells expressing MDR1*7 show a marked resistance to Ibutilide (IC 50 : 105.3±1.42 nM vs 27.4±2.5 nM) [2]. |
| In vivo | Ibutilide effectively prolongs cardiac repolarization both in vitro and in vivo, with its administration in cumulative doses (0.01, 0.02, and 0.05 mg/kg i.v., each delivered over 10 minutes) inducing both polymorphic and monomorphic non-sustained ventricular tachycardia. In a study involving fifteen adult mongrel dogs of either sex, it was shown that at a dosage of 0.01 mg/kg, Ibutilide significantly extends the action potential duration at 90% (APD90) in subjects with congestive heart failure (CHF) compared to controls. Furthermore, this dosage resulted in an increased dispersion of left-right ventricular APD90 in CHF subjects, an effect not observed in the control group. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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