HIF-1/2α-IN-2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: HIF-1/2α-IN-2 | CAS No.: 862974-22-9 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | HIF-1/2α-IN-2 |
| Description | HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α that effectively reduces HIF-1/2α levels and elicits an iron starvation response by specifically targeting ISCA2, a key protein in Iron-Sulfur Cluster Assembly 2. [1] |
| In vitro | HIF-1/2α-IN-2 (compound #1), at concentrations of 0 to 25 μM over 24 hours, primarily reduces HIF-2α translation rather than transcription, leading to decreased VEGFA and POU5F1 transcription without significantly affecting EPAS1 (HIF-2α) [1]. At 0 to 100 μM, the same compound inhibits luciferase production in an Iron-Responsive Element (IRE) luciferase reporter driven by HIF-2α, with an IC 50 value of 3.9 μM, thus effectively blocking IRE-dependent HIF-2α translation [1]. Additionally, at 0, 10, and 50 μM, HIF-1/2α-IN-2 protects ISCA2 from Pronase-mediated degradation at 4 μg/mL, and at 1.5 μM, it causes accumulation of iron and metals in normoxia 786-0 cells by targeting ISCA2 [1]. At concentrations up to 100 μM over 24 hours, it inhibits ISCA2 and induces ferroptosis [1]. Western blot analysis with normoxia 786-0 cells and hypoxic ACHN cells, exposed to 0, 1, 5, 10, and 25 μM for 24 hours, reveals decreased protein levels of HIF-2α, FTH1, ISCA2, and increased IRP2 protein levels at concentrations over 10 μM in 786-0 cells, and decreased HIF-2α and FTH1 levels at 1 μM in ACHN cells [1]. Cell viability assays indicate that HIF-1/2α-IN-2 inhibits 786-0 cell viability by inducing ferroptosis, with an IC 50 value of 22.0 μM [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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