Product Details
| Product Name:
HFI-419 |
CAS No.:
1110650-72-0 |
| Supply Ability:
10g |
Release date:
2025/04/28 |
Product Introduction
Bioactivity
| Name | HFI-419 |
| Description | HFI-419 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) with a K i value of 0.48 μM. It is utilized in research pertaining to cognitive and memory impairments, including Alzheimer's disease, brain trauma, and stroke [1]. |
| In vitro | HFI-419 effectively inhibits the Insulin-Regulated Aminopeptidase (IRAP) with a K_i value of 0.48 μM [1]. At a concentration of 1 μM, HFI-419 demonstrates a rapid decrease in presence, attributed to nonenzymatic processes, including amide hydrolysis [1]. |
| In vivo | HFI-419, administered intravenously (i.v) and intraperitoneally (i.p) at doses of 2 mg/kg and 10 mg/kg, demonstrates significant brain exposure and potent inhibition of IRAP [1]. Utilized in a Sprague-Dawley rat model [1], the compound was noted for its brief apparent elimination half-life, high plasma clearance, and extensive volume of distribution, while effectively extending the apparent half-life to 4.6 hours. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
-
CAS:2966790-98-5
$0.00 / 50mg
-
CAS:2338764-89-7
$1980.00 / 50mg
-
CAS:332164-34-8
$128.00 / 5mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States