Product Details
| Product Name:
H1k |
Purity:
98.38% |
| Supply Ability:
10g |
Release date:
2025/04/29 |
Product Introduction
Bioactivity
| Name | H1k |
| Description | H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1. |
| In vitro | H1k (72 h) exhibits anti-proliferative activity against LS-180, HepG-2, SGC-7901, A549, and MDA-MB-231 cells, with IC50 values of 2.9, 9.6, 12.1, 14.8, and 20.5 μM respectively [1].H1k (0-50 μM; 24 h) triggers significant G2-M arrest in MDA-MB-231 and SGC-7901 cells in a dose-dependent manner [1].
H1k (0-20 μM; 6 h; MDA-MB-231 cells) induces autophagy to exert its anti-proliferative activity, with lysosomes being its functional target [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.9 mg/mL (10 mM), Sonication is recommended.
|
| Keywords | CDK1 |
| Inhibitors Related | Ribociclib | Ro-3306 | Abemaciclib | Rafoxanide | AT7519 | Palbociclib monohydrochloride | CASIN | GW 441756 | Sodium Oxamate | Seliciclib | Abemaciclib methanesulfonate | Dinaciclib |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States