
GSK-843 NEW
Price | $149 |
Package | 1mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2025-07-20 |
Product Details
Product Name: GSK-843 | CAS No.: 1601496-05-2 |
Purity: 99.18% | Supply Ability: 10g |
Release date: 2025/07/20 |
Product Introduction
Bioactivity
Name | GSK-843 |
Description | GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation. |
In vitro | RIP3i GSK-843 and GSK-872 by screening conventional small molecule libraries. These compounds bound RIP3 kinase domain with high affinity (IC50 = 8.6 nM and 1.8 nM, respectively,and inhibited kinase activity (IC50 = 6.5 nM and 1.3 nM, respectively[1]. |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | DMSO : 30 mg/mL (79.47 mM), Sonication is recommended. |
Keywords | RIPkinase | RIP3 | RIP kinase | GSK-843 | GSK843 | GSK 843 |
Inhibitors Related | Flizasertib | PK68 | Necrostatin-1 | Oditrasertib | LY-364947 | RIPK2-IN-3 | Necroptosis-IN-1 | ICCB-19 hydrochloride | Necrostatin-34 | RIPA-56 | GSK2983559 free acid | Zharp2-1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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