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Postion:Product Catalog >GSK-843
GSK-843
  • GSK-843

GSK-843 NEW

Price $149
Package 1mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-20

Product Details

Product Name: GSK-843 CAS No.: 1601496-05-2
Purity: 99.18% Supply Ability: 10g
Release date: 2025/07/20

Product Introduction

Bioactivity

NameGSK-843
DescriptionGSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.
In vitroRIP3i GSK-843 and GSK-872 by screening conventional small molecule libraries. These compounds bound RIP3 kinase domain with high affinity (IC50 = 8.6 nM and 1.8 nM, respectively,and inhibited kinase activity (IC50 = 6.5 nM and 1.3 nM, respectively[1].
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 30 mg/mL (79.47 mM), Sonication is recommended.
KeywordsRIPkinase | RIP3 | RIP kinase | GSK-843 | GSK843 | GSK 843
Inhibitors RelatedFlizasertib | PK68 | Necrostatin-1 | Oditrasertib | LY-364947 | RIPK2-IN-3 | Necroptosis-IN-1 | ICCB-19 hydrochloride | Necrostatin-34 | RIPA-56 | GSK2983559 free acid | Zharp2-1

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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