GSK-3β inhibitor 8 NEW
| Price | Get Latest Price |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-13 |
Product Details
| Product Name: GSK-3β inhibitor 8 | CAS No.: 1139875-74-3 |
| Supply Ability: 10g | Release date: 2025/06/13 |
Product Introduction
Bioactivity
| Name | GSK-3β inhibitor 8 |
| Description | GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation. |
| In vitro | GSK-3β inhibitor 8 (Compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. GSK-3β inhibitor 8 (2 μM; 72 h) increases replicating R7T1 β cells approximately 2-fold.[1] GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces activation of the Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM.[1] GSK-3β inhibitor 8 (2 μM; 72 h) stimulates β-catenin translocation into the nucleus in HEK293 cells.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
| Solubility Information | DMSO : Soluble |
| Keywords | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | GSK-3β inhibitor 8 | GSK-3β | GSK3beta Inhibitor XVIII | GSK-3beta inhibitor 8 | GSK3b Inhibitor XVIII | GSK-3b inhibitor 8 | GSK3 | beta-catenin | betacatenin | bcatenin |
| Inhibitors Related | Urea | Cromolyn sodium | Wnt pathway activator 1 | TNIK-IN-3 | GSK 3 Inhibitor IX | CHIR-99021 | AT7519 | 4-Chloro-2'-bromoacetophenone | XAV-939 | GSK-3 Inhibitor 5 | Nefopam hydrochloride | Bisdemethoxycurcumin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $71.00/1mg |
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HangZhou RunYan Pharma Technology Co.,LTD.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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