GRGDSPK acetate NEW
| Price | $82 | $188 | $277 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-31 |
Product Details
| Product Name: GRGDSPK acetate | CAS No.: 144027-77-0 |
| Purity: 97.9% | Supply Ability: 10g |
| Release date: 2025/07/31 |
Product Introduction
Bioactivity
| Name | GRGDSPK acetate |
| Description | GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption. |
| In vitro | By measuring calcium content and 70 bonehnit area of tissue in parietal bones 18 days old isolated from pregnant Sprague-Dawley rats, we know that GRGDSPK (EMD 56574; RGD; 0.1-50 μM; for 4 days) inhibits mineralization in a dose-dependent manner.[1] Treatment with GRGDSPK (10 and 50 μM; 4-day treatment) results in significant alterations in bone morphology, characterized by disruptions in the organization of osteoblasts and the mineralized matrix.[1] In the presence of GRGDSPK peptide (RGD; 250 μM), added to the medium, the binding between integrins and fibronectin is effectively blocked, leading to a considerable increase in the average size of cell aggregates in wild-type cells.[2] Addition of GRGDSPK (250 μM) leads to a significant reduction in adhesion forces and work exerted by wild-type mesendodermal progenitors, indicating the involvement of integrins expressed in these progenitors and the specificity of the detachment parameters recorded for fibronectin.[2] GRGDSPK (RGD-containing, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-modified peptides, at concentrations of 1.5 mM, 1.0 mM, and 0.5 mM, impair the fertilization ability of bovine oocytes by sperm cells, resulting in a dose-dependent reduction in cleavage rates.[3] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 7.76 mg/mL (10 mM), Sonication is recommended. |
| Keywords | βAmyloid | β Amyloid | GRGDSPK Acetate | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | amyloid-β peptides |
| Inhibitors Related | BSBM7 | Notoginsenoside R1 | Geniposide | Deferoxamine Mesylate | Tramiprosate | 20(S)-Ginsenoside Rg3 | PQM130 | Dihydroergocristine mesylate | Rutin | Human serum albumin | Methyl tridecanoate | Ginsenoside Re |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Peptide Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP1Y
|
Shaanxi Xianhe Biotech Co., Ltd
|
2025-04-17 | |
| $80.00/100G |
VIP1Y
|
Handan City Zechi trading Co., LTD
|
2025-07-03 | |
| $0.00/25Kg/Bag |
VIP6Y
|
Hebei Mujin Biotechnology Co.,Ltd
|
2021-10-08 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY