GPX4-IN-4 NEW
| Price | $1670 | $2180 | $2800 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-02 |
Product Details
| Product Name: GPX4-IN-4 | CAS No.: 2920221-53-8 |
| Supply Ability: 10g | Release date: 2025/05/02 |
Product Introduction
Bioactivity
| Name | GPX4-IN-4 |
| Description | GPX4-IN-4 (Compound 24) is a potent inhibitor of GPX4, employed in cancer research [1]. |
| In vitro | GPX4-IN-4 (Compound 24) reduces HT1080 cell viability in a dose- and time-dependent fashion at concentrations ranging from 0 to 1000 nM and durations up to 24 hours [1]. Similarly, GPX4-IN-4 demonstrates inhibitory effects on NCI-H1703 cell viability over 72 hours, with EC50 values of 0.117 μM without Fer-1 and 4.74 μM with Fer-1 [1]. |
| In vivo | GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) targets renal GPX4 and induces the expression of PD biomarkers in mice [1]. Despite partial target engagement observed in tumor masses, GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) does not affect the growth of WSU-DLCL2 tumors in mice [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | GlutathionePeroxidase | Glutathione Peroxidase |
| Inhibitors Related | AZD8309 | ML-210 | RSL3 | ML162 | PF-1355 | 5-Aminosalicylic Acid | Melatonin | 4-POBN | 4-Methylesculetin | Nabumetone | Cefdinir | GSTO1-IN-1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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