Gap 27 NEW
| Price | $48 | $97 | $141 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: Gap 27 | CAS No.: 198284-64-9 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | Gap 27 |
| Description | Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker. |
| In vitro | Gap 27 significantly reduces the population of TRAP-positive mononuclear and multinucleated rat osteoclasts on bovine bone slices and decreases the functionality of remaining osteoclasts, as demonstrated by a lower percentage of osteoclasts displaying actin rings among all TRAP-positive cells. Moreover, the area resorbed by these treated cultures is substantially reduced[1]. When applied to the carotid artery, Gap 27 at a concentration of 500 μM effectively eliminates the hyperpolarization response to acetylcholine, but does not affect the response to levcromakalim, indicating a specific inhibition of acetylcholine-induced, endothelium-dependent hyperpolarizations in the guinea-pig-isolated internal carotid artery[2]. |
| In vivo | Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta but did not modify force development in response to PhE[3]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Insoluble H2O : 10 mM, Sonication is recommended. |
| Keywords | Inhibitor | inhibit | GapJunctionProtein | Gap-27 | Gap27 | Gap Junction Protein | Gap 27 |
| Inhibitors Related | Meclofenamic acid sodium | Carvedilol phosphate hemihydrate | Rotigaptide TFA(355151-12-1 free base) | Meclofenamic acid | Gap 26 | Danegaptide Hydrochloride | Peptide5 TFA | TAT-Gap19 acetate | Larazotide acetate | Carbenoxolone disodium | Gap19 | Carbenoxolone |
| Related Compound Libraries | Cyclic Peptide Library | Bioactive Compound Library | Peptide Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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