GA-017 NEW
| Price | $116 | $289 | $447 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-16 |
Product Details
| Product Name: GA-017 | CAS No.: 2351906-74-4 |
| Purity: 98.82% | Supply Ability: 10g |
| Release date: 2025/06/16 |
Product Introduction
Bioactivity
| Name | GA-017 |
| Description | GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1]. |
| In vitro | GA-017 suppresses the HUVECs cell death and promotes their cell growth [1]. GA-017 facilitates SKOV3 cell growth, with an EC 50 of 3.51 ± 0.26 μM [1]. GA-017 competitively inhibited LATS1 and 2 against ATP, with K i (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 18.9 mg/mL (55 mM), Sonication and heating to 80℃ are recommended. |
| Keywords | Lats2 | Lats1 | GA-017 | GA017 | GA 017 |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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