Fulvene-5 NEW
| Price | $1980 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: Fulvene-5 | CAS No.: 1075723-01-1 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | Fulvene-5 |
| Description | Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen species (ROS) modifying agent and a powerful radioprotector. |
| In vitro | Fulvene-5, administered at concentrations of 0.5-1.0 μM, significantly reduces the levels of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in bEnd.3 cells in a dose-dependent fashion. At a higher concentration (10?μM for 1 hour), Fulvene-5 shifts the adaptive responses of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures from promoting survival towards enhancing sensitivity to radiation, and inversely. These alterations coincide with the moving of survivin into the nuclei in TP53 WT cells and out to the cytoplasm in TP53 Mut cells. Additionally, the involvement of NOX4 in survivin-related adaptive responses is explored by diminishing NOX4 expression through the transfection of HCT116 cells with NOX4 siRNA oligomers, achieving approximately a 50% reduction in NOX4 expression. |
| In vivo | Fulvene-5??treatment potently inhibits hemangioma growth in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | NADPH oxidase 4 (NOX4) | Fulvene-5 | Fulvene5 | Fulvene 5 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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